Express Scripts spokesman Brian Henry said in an interview Thursday that the office had become unnecessary because computerized systems had reduced the number of people necessary to process prescriptions.
Some 50 workers at the Trevose office are being given the opportunity to work from home or at another site, Henry said. Express Scripts employs about 2,000 people statewide, with offices in Blue Bell, North Huntingdon, and Warrendale, he said.
The Trevose facility will close May 26. The company's lease for the space expires at the end of June.
Express Scripts is the nation's largest stand-alone pharmacy benefits manager, with $100.3 billion in revenue in 2016, according to its most recent annual report.