The Quakers rallied back from a 15-point deficit, but fell just short of the comeback in a road loss to the Crimson.
Eleah Parker led Penn (17-7, 8-3 Ivy League) with 14 points and eight rebounds. Anna Ross, shooting 3-for-11 from the field, finished with eight points, six rebounds, and five assists. Michelle Nwokedi scored six points on 3-for-13 shooting and grabbed 11 rebounds.
Harvard's Taylor Rooks recorded a double-double with 21 points and 12 rebounds.
Kelly Jekot scored a game-high 15 points to lead the Wildcats in a blowout win over the Friars at home.
Alex Louin and Mary Gedaka finished with 13 points each for Villanova (21-7, 11-6 Big East), and Jannah Tucker added 12 points.
Aubree Brown recorded 26 points and six rebounds to lead the Dragons in a win over the visiting Dukes after double overtime.
Kelsi Lidge had seven points, six rebounds, and six assists, while Sara Woods added 17 points and seven rebounds for Drexel (21-6, 13-2 Colonial Athletic Association).